In his final contribution to the psychoanalytic literature published two months before his untimely death on December 21, 2000, the late Stephen A. Mitchell provided a brilliant synthesis of the interrelated ideas that hover around, and describe aspects of, the relational matrix of human experience. Relationality charts the emergence of the relational perspective in psychoanalysis by reviewing the contributions of Loewald, Fairbairn, Bowlby, and Sullivan, whose voices converge in apprehending the fundamental relationality of mind. Mitchell draws on the multiple dimensions of attachment, intersubjectivity, and systems theory in espousing a clinical approach equally notable for its responsiveness and responsible restraint. Relationality “signals a new height in Mitchell’s always illuminating writing” (Nancy Chodorow) and marks the “coming of age” of the relational perspective in psychoanalysis (Peter Fonagy).