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PEDAL Hub Library

We’ve rounded up a set of high-quality play resources for you to explore. The library houses a collection of links that will take you to peer-reviewed publications, videos of play experts, and websites that may be of interest to you.

You can use the filters below to find the resources that best match your interests. The library can be sorted by format (journal papers, videos, blogs etc.), child age, and type of play.

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Preclinical Modeling of Primal Emotional Affects (SEEKING, PANIC and PLAY): Gateways to the Development of New Treatments for Depression

Mammalian brains contain at least 7 primal emotional sys- tems – SEEKING, RAGE, FEAR, LUST, CARE, PANIC and PLAY (capitalization reflects a proposed primary-process terminol- ogy, to minimize semantic confusions and mereological falla- cies). These systems help organisms feel affectively balanced (e.g. euthymic) and unbalanced (e.g. depressive, irritable, manic), providing novel insights for understanding human […]

Title: Preclinical Modeling of Primal Emotional Affects (SEEKING, PANIC and PLAY): Gateways to the Development of New Treatments for Depression
Abstract:

Mammalian brains contain at least 7 primal emotional sys- tems – SEEKING, RAGE, FEAR, LUST, CARE, PANIC and PLAY (capitalization reflects a proposed primary-process terminol- ogy, to minimize semantic confusions and mereological falla- cies). These systems help organisms feel affectively balanced (e.g. euthymic) and unbalanced (e.g. depressive, irritable, manic), providing novel insights for understanding human psychopathologies. Three systems are especially important for understanding depression: The separation distress (PAN- IC) system mediates the psychic pain of separation distress (i.e. excessive sadness and grief), which can be counteracted by minimizing PANIC arousals (as with low-dose opioids). De- pressive dysphoria also arises from reduced brain reward- seeking and related play urges (namely diminished enthusi- asm (SEEKING) and joyful exuberance (PLAY) which promote sustained amotivational states). We describe how an under- standing of these fundamental emotional circuits can pro- mote the development of novel antidepressive therapeutics – (i) low-dose buprenorphine to counteract depression and suicidal ideation emanating from too much psychic pain (PANIC overarousal), (ii) direct stimulation of the SEEKING sys- tem to counteract amotivational dysphoria, and (iii) the dis- covery and initial clinical testing of social-joy-promoting mol- ecules derived from the analysis of the PLAY system.

Publication year: 2014
Date: 28/07/2022
Volume: 47
Page/s: 383-393

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